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Diurnal blood sampling and temperature assessment to study the body s internal clock. Primary Outcome Measures : Phenotype physical and behavioral traits of overweight and obese people [ Time Frame: Two weeks ] The aim of this study is to extensively phenotype subjects with varying degrees of obesity, as well as those with rare adipose disorders such as multiple symmetric lipomatosis Madelung s diseaseDercums disease adiposis dolorosa and lipedema; to assess their hormonal, metabolic, cognitive and behavioral traits.

People over 18 years of age from all weight lean, overweight, obese who are reasonably healthy may be eligible for this study. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or information. Treadmill or bicycle exercise capacity test. Genetic material will be collected for studies of the internal codes that influence body weight.

Study Description. Although complex metabolic, hormonal, and neural networks operate to control body weight, obesity is in most cases, the result of over-feeding and inactivity. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.

N Engl J Med. Epub Aug Overweight, obesity, and mortality from cancer in dating Illinois a fat woman prospectively studied cohort of U. Years of life lost due to obesity. Diabetes Care. In order to explore the factors that impede weight loss and result in weight regain, the obese phenotype and its variants must be defined. Lean individuals will be recruited to create a normative database for body composition dual energy x-ray absortiometry, air displacement plethysmographyenergy expenditure resting energy expenditure, 24h respiratory chamber and doubly labeled water and other techniques used to study traits of importance.

Air-displacement plethysmography Bod Pod to measure body composition. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. The contributions of behavior, environment, socioeconomic status, physiology and genetics assure that no single therapeutic regimen will be successful in all obese individuals. Current, unstable medical conditions including cardiac ischemia; severe respiratory insufficiency requiring oxygen therapy; hepatic or cardiac failure as assessed by history and physical exam; Any psychiatric condition that would preclude participation in the study; Patients unwilling or unable to give informed consent.

Physical activity monitor. Epub Mar 2. Participants undergo the following tests and procedures: Physical exam, electrocardiogram, blood and urine tests, instructions for recording food intake for 7 days Metabolic studies for menstruating women. Unicorder to detect any breathing difficulties that may interfere with sleep. Contacts and Locations.

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Dual energy x-ray absortiometry DEXA to measure body fat and bone density. Eligibility Criteria. Repeat hour energy expenditure.

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Importantly, this protocol is the means by which pilot data are obtained to develop novel approaches and hypotheses for studying obesity and its associated traits. Read our disclaimer for details.

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Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Glucose tolerance test to determine how sensitive the body is to insulin. Participants undergo the following tests and procedures:. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. Study of the Phenotype of Overweight and Obese Adults.

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While childhood obesity is an important public health issue, the variables of growth and hormonal controls will be delineated in separate studies. Neurocognitive testing to check memory, decision-making, hand-eye coordination, and reasoning. Please refer to this study by its ClinicalTrials. Control subjects may be matched for age, sex and years of education :. Occupational therapy evaluation to explore the subject s adaptations, if any, for performing personal, social or professional activities; the subject s views on his or her weight, body size and shape, and strategies to control weight.

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Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. For general information, Learn About Clinical Studies. Doubly labeled water to measure the amount of calories burned in a 7-day period.

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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Obese men and women over the age of 18 years with BMI greater than 30, who are reasonably healthy. Resting metabolic rate to study how many calories the body burns at rest.

This study will describe the phenotype physical and behavioral traits of overweight and obese people.

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Over-weight and obese patients are encouraged to participate in as full an evaluation as feasible. More Information. Actual Study Start Date :.

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Taste testing to determine the response to bitter, salty, sweet and sour substances. Last Update Posted : April 12, See Contacts and Locations. Search for terms.

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Listing a study does not mean it has been evaluated by the U. Federal Government. Epub Mar Core body temperature in obesity. The purpose of this study is to detail hormonal, metabolic, cognitive and behavioral traits across the spectrum of weight utilizing the state-of the-art facilities of the Metabolic Units at the Mark O. Genetic material will be banked for analysis of phenotypic subgroups as they emerge.

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Pregnant women Additional exclusion for lean control subjects: history of obesity as an adolescent or adult; Current or past history of eating disorders such as anorexia nervosa or bulimia. Evaluation of mood problems and assess personality type. Save this study. Epub Feb Epub May Metabolic effects of chronic cannabis smoking. Obesity Healthy Volunteers. Endothelial reactivity to measure how the blood vessels stretch or dilate for assessing cardiovascular health.

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Study Type :. Mixed meal test to measure hormones such as insulin that regulate blood sugar.

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Overweight men and women over the age of 18 years with BMI greater than 25 and less than 30, who are reasonably healthy. January 30, Key Record Dates. Behavior is controlled to some degree by conscious decision making and is influenced by als from the integrated networks involved in body weight regulation. Estimated Enrollment :.

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Patients over the age of 18 are eligible for this study. J Clin Endocrinol Metab. Talk with your doctor and family members or friends about deciding to a study. Study record managers: refer to the Data Element Definitions if submitting registration or information. Bromide dilution to measure the amount of water not in cells in the body.

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In the majority of obese patients, patterns of fundamental behavior determine the success or failure of weight loss interventions. The study will be conducted in both the inpatient and outpatient setting and can include evaluation of hormones, diurnal variation, sleep, eating behavior and taste perception, physical fitness, psychological and neurocognitive functioning. It will characterize the hormones, metabolism, food preferences, fitness and physical activity levels, sleep patterns and thought processes in people with and without weight problems.

Warning You have reached the maximum of saved studies Physical and Behavioral Traits of Overweight and Obese Adults The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Anthropometric measurements and bioelectrical impedance to measure height, weight, and circumferences, skinfold thickness, fluid status and percentage body fat.

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Outcome Measures. Detailed Description:.

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Am J Clin Nutr. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. Evaluation to assess the quantity and quality of pain experienced. Fat and muscle biopsy to look for variations in gene expression in fat tissue and muscle.